Session

Regulation of urothelium carcinogenesis and progression

Poster Session 63

  • Location:
    Room Paris (Hall B2, level 0)
  • Chairs:
     B.C. Jeong, Seoul (KR)
     A. Vlahou, Athens (GR)
     E. Zwarthoff, Rotterdam (NL)
  • Aims and objectives of this session

    Factors from tumour microenvironment are recognised as regulators of cancer progression. In this session, novel chemokines and miRNA which have a key role in bladder carcinogenesis will be discussed.

  • Poster viewing of 20 minutes. Presentations will take place on stage. Standard presentations are 2 minutes in length, followed by 2 minutes for discussion.
787
The Cancer Genome Atlas (TCGA) project analysis of micro-RNA and gene expression subtypes of high-grade, muscle-invasive urothelial carcinoma

By: Robertson G.2, Gunaratne P.3, Lerner S.1, Mungall A.2, Brooks D.2, Bowlby R.2, Sipahimalani P.2, Jones S.2, Marra M.2, Hoadley K.4, Kwiatkowski D.5, Rosenberg J.6, Weinstein J.7

Institutes: 1Baylor College of Medicine, Dept. of Urology, Houston, United States of America, 2BC Cancer Agency, Genome Sciences Center, Vancouver, Canada, 3University of Houston, Dept. of Biology & Biochemistry, Houston, United States of America, 4University of North Carolina, Dept. of Genetics, Chapel Hill, United States of America, 5Harvard, Broad Institute, Boston, United States of America, 6Memorial Sloan Kettering Cancer Center, Dept. of Medical Oncology, New York, United States of America, 7MD Anderson Cancer Center, Computational Biology, Houston, United States of America

788
Robust cancer-specific gene expression by a cassette with hTERT and CMV promoter elements as a novel system for detecting viable bladder cancer cells

By: Sadahira T., Watanabe M., Araki M., Ebara S., Watanabe T., Nasu Y.

Institutes: Okayama University Graduate School, Dept. of Urology, Okayama, Japan

789
Comprehensive analysis of immune infiltrates during BCG therapy reveals an immune profile strongly associated with bladder cancer recurrence

By: Chevalier M.F.1, Trabanelli S.2, Gharbi D.1, Cesson V.1, Domingos-Pereira S.1, Dartiguenave F.1, Fritschi A-S.1, Speiser D.2, Romero P.2, Jandus C.2, Nardelli-Haefliger D.1, Derré L.1, Jichlinski P.1

Institutes: 1Lausanne University Hospital, Dept. of Urology, Lausanne, Switzerland, 2University of Lausanne, Dept. of Cancer Research, Epalinges, Switzerland

790
CXCL1 signalling is a crucial mediator between cancer cells and tumour-associated macrophages/cancer-associated fibroblasts for tumour invasion and progression in micro-environment of human bladder cancer

By: Miyake M.1, Hori S.1, Morizawa Y.1, Tatsumi Y.1, Nakai Y.1, Anai S.1, Tanaka N.1, Toritsuka M.2, Kishimoto T.2, Rosser C.3, Fujimoto K.1

Institutes: 1Nara Medical University, Dept. of Urology, Kashihara-Shi, Japan, 2Nara Medical University, Dept. of Psychiatry, Kashihara-Shi, Japan, 3University of Hawaii Cancer Center, Dept. of Clinical and Translational Research, Honolulu, United States of America

791
Notch2-HEY axis promotes tumour growth in bladder cancer through cell cycle progression and de-differentiation

By: Hayashi T.1, Goriki A.2, Oo H.Z.2, Seiler R.2, Todenhofer T.2, Jaeger W.2, Awrey S.2, Altamirano-Dimas M.2, Fazli L.2, Matsubara A.1, Black P.2

Institutes: 1Hiroshima University, Dept. of Urology, Hiroshima, Japan, 2Vancouver Prostate Centre, Dept. of Urology, Vancouver, Canada

792
Advanced two-step transcriptional amplification as a novel system for cancer-specific gene expression and imaging

By: Sadahira T., Watanabe M., Araki M., Ebara S., Watanabe T., Nasu Y.

Institutes: Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Dept. of Urology, Okayama, Japan

793
Relationship of СMV infection with transitional cell carcinoma of bladder

By: Kosova I.

Institutes: Moscow City Hospital №68, Dept. of Urology, Moscow, Russia

794
Stabilization of invadopodia by plectin-mediated conjunction to vimentin intermediate filament is a critical molecular step of invasion and extravasation for metastasis in bladder cancer

By: Yoneyama M.S.1, Hatakeyama S.2, Habuchi T.3, Inoue T.3, Nakamura T.4, Funyu T.1, Wiche G.5, Tsuboi S.1, Ohyama C.2

Institutes: 1Oyokyo Kidney Research Institute, Dept. of Cancer Immunology and Cell Biology, Hirosaki, Japan, 2Graduate School of Medicine, Hirosaki University, Dept. of Urology, Hirosaki, Japan, 3Akita University, Dept. of Urology, Akita, Japan, 4Graduate School of Health Sciences, Hirosaki University, Dept. of Biomedical Sciences, Hirosaki, Japan, 5Vienna University, Dept. of Biochemistry and Cell Biology, Vienna, Austria

795
Combination of human immunodeficiency virus protease inhibitors causes bladder cancer apoptosis synergistically by inducing endoplasmic reticulum stress and histone acetylation

By: Sato A., Asano T., Isono M., Okubo K., Ito K., Asano T.

Institutes: National Defense Medical College, Dept. of Urology, Tokorozawa, Japan

796
CCDC34 is up-regulated in bladder cancer and regulates bladder cancer cell proliferation, migration and invasion

By: Gong Y.1, Qiu W.2, Ning X.1, Yang X.1, Li X.1, Guo Y.1

Institutes: 1Peking University First Hospital, Dept. of Urology, Beijing, China, 2Beijing Friendship Hospital, Capital Medical University, Dept. of Urology, Beijing, China

797
MicroRNA-145 promotes differentiation in human urothelial carcinoma through down-regulation of syndecan-1

By: Fujii T.1, Tatsumi Y.1, Asano A.1, Izutsu C.1, Fujimoto K.2, Konishi N.1

Institutes: 1Nara Medical University, Dept. of Pathology, Kashihara, Nara, Japan, 2Nara Medical University, Dept. of Urology, Kashihara, Nara, Japan

798
Uncovering the TWEAK/Fn14 cytokine-receptor axis in bladder cancer

By: Pompas-Veganzones N.1, Calvo R.1, Sanchez-Niño M.D.2, Dominguez O.3, Ortiz A.2, Gonzalez-Peramato P.4, Sanchez-Carbayo M.1

Institutes: 1University of the Basque Country, Dept. of Translational Oncology Laboratory, Vitoria-Gasteiz, Spain, 2Fundacion Jimenez Diaz, Dept. of Nephrology, Madrid, Spain, 3Spanish National Cancer Research Center, Dept. of Genomics, Vitoria-Gasteiz, Spain, 4Hospital La Paz, Dept. of Pathology, Madrid, Spain

799
Exosomal miRNAs: Key regulators of cell-cell communication among bladder cancer cells and tumor microenvironment?

By: Baumgart S.1, Heinzelmann J.1, Krause E.2, Stöckle M.1, Stampe Ostenfeld M.3, Junker K.1

Institutes: 1University Hospital of Saarland, Dept. of Urology, Homburg, Germany, 2University Hospital of Saarland, Dept. of Physiology, Homburg, Germany, 3University Hospital Aarhus, Dept. of Molecular Medicine, Aarhus, Denmark

Summary and context
 A. Vlahou, Athens (GR)